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Tuesday, July 14, 2009

Pandanus amaryllifolius:Anti-influenza


Pandanus amaryllifolius is a tropical plant in the screwpine genus which is known commonly as pandan and used widely in Southeast Asian cooking. It is an erect green plant with fan-shaped sprays of long, narrow, bladelike leaves and woody aerial roots. The plant is sterile, flowers only very rarely, and is propagated by cuttings.

The plant is rare in the wild but cultivated widely for use as a flavoring in cooking. The leaves are used fresh or wilted, and are commercially available in frozen form in Asian grocery stores in nations where the plant does not grow. They have a nutty, botanical fragrance which enhances the flavor of Indonesian, Filipino, Malaysian, Thai, Vietnamese and Burmese foods, especially rice dishes and cakes. The leaves are sometimes steeped in coconut milk, which is then added to the dish. They may be tied in a bunch and cooked with the food. They also may be woven into a basket which is used as a pot for cooking rice. Pandan chicken, or gai ob bai toey, is a Thai dish with chicken wrapped in pandan leaves and fried. The leaves are also used as a flavoring for desserts such as pandan cake and sweet beverages.

In Indonesian it is called pandan wangi, soon-mhway in Burmese, and in Vietnamese it is called lá dứa. The leaves of the plant have a repellent effect on cockroaches.

The characteristic aroma of pandan is caused by the aroma compound 2-acetyl-1-pyrroline which also gives white bread, jasmine rice and basmati rice, and bread flowers (Vallaris glabra) their typical smell.

Extracting of fluids of Pandanus amaryllifolius can surpass the normal aroma of fresh leaves

Saturday, July 11, 2009

Aloe vera anti-influenza


Aloe, also written Aloë, is a genus containing about four hundred species of flowering succulent plants. The most common and well known of these is Aloe vera, or "true aloe".

The genus is native to Africa, and is common in South Africa's Cape Province, the mountains of tropical Africa, and neighbouring areas such as Madagascar, the Arabian peninsula, and the islands off Africa.

The APG II system (2003) placed the genus in the family Asphodelaceae. In the past it has also been assigned to families Aloaceae and Liliaceae or lilly family. Members of the closely allied genera Gasteria, Haworthia and Kniphofia, which have a similar mode of growth, are also popularly known as aloes. Note that the plant sometimes called American aloe (Agave americana) belongs to Agavaceae, a different family.

Most Aloe species have a rosette of large, thick, fleshy leaves. The leaves are often lance-shaped with a sharp apex and a spiny margin. Aloe flowers are tubular, frequently yellow, pink or red and are borne on densely clustered, simple or branched leafless stems.

Many species of Aloe appear to be stemless, with the rosette growing directly at ground level; other varieties may have a branched or unbranched stem from which the fleshy leaves spring. They vary in colour from grey to bright-green and are sometimes striped or mottled. Some Aloes native to South Africa are arborescent

Historical uses

Historical use of various Aloe species by humans is well documented. Documentation of the clinical effectiveness is available, although relatively limited.

Of the 300 species of Aloe, only a few were used traditionally as a herbal medicine, aloe vera again being the most commonly used version of aloe in herbal medicine. Also included are Aloe perryi (found in northeastern Africa) and Aloe ferox (found in South Africa). The Greeks and Romans used aloe vera to treat wounds. In the Middle Ages, the yellowish liquid found inside the leaves was favored as a purgative.[citation needed] It should be noted that processed aloe that contains aloin is generally used as a laxative, whereas processed aloe vera juice that does not contain significant aloin is used for digestive healing.

Some species, particularly Aloe vera are used in alternative medicine and in the home first aids. Both the translucent inner pulp and the resinous yellow aloin from wounding the Aloe plant are used externally to relieve skin discomforts. As an herbal medicine, aloe vera juice is commonly used internally to relieve digestive discomfort "aloe for heartburn". http://findarticles.com/p/articles/mi_m0FKA/is_4_69/ai_n18791510. "aloe alt med". http://altmedicine.about.com/od/therapiesfrometol/a/heartburn.htm. "Aloe IBS study". http://www.medscape.com/viewarticle/546327. . Some modern research suggests Aloe vera can significantly slow wound healing compared to normal protocols of treatment.Other reviews of randomised and controlled clinical trials have provided no evidence that Aloe vera has a strong medicinal effect.

Today, aloe vera is used both internally and externally on humans. The gel found in the leaves is used for soothing minor burns, wounds, and various skin conditions like eczema and ringworm. The extracted aloe vera juice aloe vera plant is used internally to treat a variety of digestive conditions. The use of this herbal medicine was popularized in the 1950s in many Western countries. The gel's effect is nearly immediate; it also applies a layer over wounds that is said to reduce the chance of any infection.

There have been relatively few studies about possible benefits of Aloe gel taken internally, yet it has been found to be anti-carcinogenic.[citation needed] Data also suggest that components of Aloe inhibit tumor growth.There have been some studies in animal models which indicate that extracts of Aloe have a significant anti-hyperglycemic effect, and may be useful in treating Type II diabetes. These studies have not been confirmed in humans

Aloin in OTC laxative products

On May 9, 2002, the U.S. Food and Drug Administration issued a final rule banning the use of aloin, the yellow sap of the aloe plant for use as laxative ingredient in over-the-counter drug products.[8] Most aloe juices today do not contain significant aloin.


Chemical properties

Succulent plants, such as this Aloe, store water in their enlarged fleshy leaves, stems, or roots, as shown in this split aloe leaf. This allows them to survive in arid environments.According to W. A. Shenstone, two classes of aloins are to be recognized: nataloins, which yield picric and oxalic acids with nitric acid, and do not give a red coloration with nitric acid; and barbaloins, which yield aloetic acid (C7H2N3O5), chrysammic acid (C7H2N2O6), picric and oxalic acids with nitric acid, being reddened by the acid. This second group may be divided into a-barbaloins, obtained from Barbados Aloe, and reddened in the cold, and b-barbaloins, obtained from Socotrine and Zanzibar Aloe, reddened by ordinary nitric acid only when warmed or by fuming acid in the cold. Nataloin (2C17H13O7·H2O) forms bright yellow scales. Barbaloin (C17H18O7) prismatic crystals. Aloe species also contain a trace of volatile oil, to which its odour is due.[citation needed]

Nerium indicum


Nerium indicum is commonly known as Rose bay, Dog bane, South sea rose, Oleander ceylon tree or Adelfa (Tag., Sp.), that belongs to the Apocynaceae family. The whole plant is very poisonous, containing a powerful cardiac toxin. Ingestion of only one leaf may lead to death in children, while skin contact with the plant can cause irritation. The plant may be medicinal only if used with extreme caution. Nerium indicum is found throughout the Philippines.

Description
Nerium indicum is an evergreen, smooth shrub growing up to 4 meters in height. It is basically leafy all year and the inflorescences bloom from June to October. The flowers have both male and female organs or hermaphrodite, soft sweet-scented, single or double cymes with attractive color that varies from white, pink or red. The leaves are simple, linear-lanceolate, whorled, decussate or in pairs, usually opposite. The fruit is cylindric that grow in pairs with deep longitudinal and narrow parallel lines or ridges, about 15 to 20 centimeters long. The seeds usually are flat and winged or have a tuft of fine, shining white and grayish silky hairs.

Habitat and Distribution

Nerium indicum originated from subtropical or tropical Asia, apparently introduced by the Spaniards in the Philippines, also found in some parts of S.W. Europe. Nerium indicum best grow in river banks, river gravels, woodland garden, sunny edge and hedges

Cultivation
Nerium indicum prefers medium (loamy or soft) and heavy (clay or natural mineral aggregate) soil and can grow in heavy clay soil. It prefer neutral and basic (alkaline) soils that cannot grow in shaded areas. The plant needs moist or dry soil and can tolerate drought and maritime exposure.

Uses
-The leaves and flowers are cardiotonic (tonic effect on the heart), diaphoretic (promotes perspiration), diuretic (promotes excretion), emetic (causes vomiting), expectorant (cough remedy), sternutatory (substance) as well as treatment of malaria, dysmenorrhea and abortifacient (induces the expulsion of embryo).
-Decoction of leaves has been applied externally in the treatment of scabies and to reduce swellings.
-The root is a powerful resolvent (power to disperse inflammatory).
-The root can also be beaten into paste and applied externally to chancres (syphilis), ulcers (open sore) on the penis and haemorrhoids (dilation of the blood vessels around the anus).
-The oil prepared from the root bark is used in the treatment of leprosy and skin diseases of scaly nature.
-The whole plant is believed to have anti-cancer properties.
-The punded leaves and bark are used as an insecticide, rat poison and parasiticide.
-The leaves contain small amounts of latex that can ba used to make rubber.
-The plant is also used as soil stabilizer.

Friday, July 10, 2009

Herbs defense anti-influenza activity


1.1 พลูคาว / ผักคาวตอง (Houttuynia cordata)

จากการศึกษาในหลอดทดลอง น้ำมันระเหยการกลั่นพลูคาวสดมีฤทธิ์ต้านไวรัส ไข้หวัดใหญ่ เริม (Herpes simplex virus type 1) เอชไอวี (HIV-1) โดยสารสำคัญในน้ำมันระเหยจากพลูคาวที่มีฤทธิ์ต้านไวรัสดังกล่าว ได้แก่ methyl n-nonyl ketone, laurly aldehyde, capryl aldehyde


1.2 ทองพันชั่ง (Rhinacanthus nasutus)

ส่วนเหนือดินของทองพันชั่งมีสารสำคัญที่มีฤทธิ์ต้านไวรัสไข้หวัดใหญ่ชนิด A อย่างมีนัยสำคัญ ได้แก่ Rhinacanthin E และ Rhinacanthin F




1.3 Epigallocatechin (EGCG)

EGCG เป็นสารต้านอนุมูลอิสระที่มีมากที่สุดในชาเขียว EGCG ขนาดต่ำในหลอดทดลองมีฤทธิ์ ยับยั้งไม่ให้ไวรัสไข้หวัดใหญ่ทั้งชนิด A และ B เข้าเซลล์& ลดการติดเชื้อของเซลล์เพาะเลี้ยงจากไตสุนัขได้อย่างมีนัยสำคัญ



1.4 บีทรู้ท (Beta vulgaris)

บีทรู้ท = Beet root, sugarbeet ใช้ทำน้ำตาล เมื่อหยอดสารสกัดด้วยน้ำของบีทรู้ทเข้าจมูกหนูถีบ จักรหลายครั้ง ก่อนหยอดไวรัส H1N1 พบว่าช่วย ป้องกันการติดเชื้อไวรัสไข้หวัดใหญ่ได้บางส่วนลดปริมาณเชื้อในปอดหนู ลดอัตราการตายของหนู ยืดเวลามีชีวิตของหนู เมื่อเทียบกับหนูกลุ่มที่ได้รับไวรัสหยอดจมูกอย่างเดียว


1.5 ใบเตย (Pandanus amaryllifolius)

ใบเตยมีสารจำพวกเลกติน (lectin) ซึ่งมีคุณสมบัติเป็นโปรตีน ชื่อ Pandanin ที่มีฤทธิ์ต้านเชื้อ ไข้หวัดใหญ่ชนิด A (H1N1) อย่างมีนัยสำคัญ โดยมีค่าความเข้มข้นที่ยับยั้งเชื้อได้ 50% (EC50) เท่ากับ15.63 microM



1.6 สาร Aloe emodin

Aloe emodin = สารแอนทราควิโนน (anthraquinone) ที่พบได้ในยางว่านหางจระเข้ เมื่อนำสาร Aloe emodin มาผสมกับไวรัสไข้หวัดใหญ่ในหลอดทดลองนาน 15 นาที ที่ 37 องศาเซลเซียส สามารถยับยั้งไวรัสไข้หวัดใหญ่ได้ นอกจากนี้ สาร aloe emodin ยังยับยั้งไวรัสที่ก่อโรคเริม และงูสวัดได้อีกด้วย



1.7 ยี่โถ (Nerium indicum)

สารสกัดด้วยเมทานอล และสารสกัดด้วยเมทานอลกับน้ำของยี่โถมีฤทธิ์ต้านเชื้อไข้หวัดใหญ่ได้ดี โดยมีค่าความเข้มข้นที่ยับยั้งเชื้อได้ 50% (IC50) เท่ากับ 10 ไมโครกรัมต่อมิลลิลิตร

Saturday, July 4, 2009

Solanum trilobatum Linn.


Solanum, the nightshades, horsenettles and relatives, is a large and diverse genus of annual and perennial plants. They grow as forbs, vines, sub-shrubs, shrubs, and small trees, and often have attractive fruit and flowers. Many formerly independent genera like Lycopersicon (the tomatoes) or Cyphomandra are included in Solanum as subgenera or sections today. Thus, the genus nowadays contains roughly 1,500-2,000 species.

Most parts of the plants, especially the green parts and unripe fruit, are poisonous to humans (albeit not necessarily to other animals), but many species in the genus bear some edible parts, such as fruits, leaves, or tubers. Several species are cultivated, including three globally important food crops:

Tomato, S. lycopersicum
Potato, S. tuberosum
Eggplant, S. melongena
Other species are significant food crops regionally, such as Ethiopian Eggplant and gilo (S. aethiopicum), naranjilla or lulo (S. quitoense), Turkey Berry (S. torvum), or the "bush tomatoes" (several Australian species).

While most medical relevance of Solanum is due to poisonings which are not uncommon and may be fatal, several species are locally used in folk medicine, particularly by native peoples who have long employed them. Giant Devil's-fig (S. chrysotrichum) has been shown to be an effective treatment for seborrhoeic dermatitis in a scientific study[1].

Solanum species are used as food plants by the larvae of some Lepidoptera species (butterflies and moths) - see list of Lepidoptera that feed on Solanum.

Monday, June 29, 2009

Thai Herbal Medicine Research

Monday, June 22, 2009

Houttuynia Cordata thumb


ฤทธิ์ทางเภสัชวิทยา ที่เกี่ยวกับผักคาวตอง คือ

— ฤทธิ์ในการบำบัดฟื้นฟู โรคความดันโลหิตสูง (Artrosclerosis)

— ฤทธิ์ในการทำลายเซลล์มะเร็ง (Cytotoxicity Against Tunor Cellines)

— เซลล์มะเร็งปอด เซลล์มะเร็งรังไข่ เซลล์เนื้องอกที่เป็นเนื้อร้าย เซลล์มะเร็งสมอง มะเร็งลำไส้ มีฤทธิ์

ทำลายเซลล์มะเร็งแต่ละชนิดอย่างมีนัยสำคัญ

— ฤทธิ์ยับยั้งการเจริญเติบโตของเซลล์มะเร็งเม็ดเลือดขาว (Antileukemic Activty)

— ฤทธิ์เพิ่มภูมิคุ้มกันหรือภูมิต้านทานโรค ยับยั้งเนื้องอก กระตุ้นเซลล์น้ำเหลือง ยับยั้งเบาหวาน

รักษาความสมดุลของร่างกายและอื่นๆ

— ฤทธิ์กับการติดเชื้อไวรัส กระตุ้นเซลล์เพิ่มภูมิคุ้มกัน ป้องกันไข้ทรพิษ หัด หัดเยอรมัน การติดเชื้อทาง

เดินหายใจ HIV เริม งูสวัด

— ฤทธิ์เกี่ยวกับการต้านเชื้อราและแบคทีเรีย เยื่อหุ้มสมองอักเสบที่เกิดจากเชื้อรา Cryptocoecus

Neoformans) ทางเดินปัสสาวะอักเสบ การติดเชื้อทางเดินหายใจ โรคทางเดินอาหาร โรคปริทันต์ โรค

ระบบสืบพันธุ์ กลากเกลื้อน โรคติดเชื้อในปาก

— ฤทธิ์ต้านการอักเสบต่างๆ (Anti – Inflamnation) ยับยั้งเอนไซม์ (Cyclooxygenase) บ่อเกิดโรคที่มี

อาการอักเสบ

— ฤทธิ์ขับปัสสาวะ (Diuretic Actuvity) ขยายหลอดเลือด ทำให้อัตราไหลเวียนของเลือดและขับปัสสาวะ

เพิ่มขึ้น